Publications

2005-2008

Singh RP, Brooks BR, Klauda JB. Binding and release of cholesterol in the Osh4 protein of yeast. Proteins. 2008.

Rosales T, Xu J, Wu X, Hodoscek M, Callis P, Brooks BR, Knutson JR. Molecular dynamics simulations of perylene and tetracene librations: comparison with femtosecond upconversion data. J Phys Chem A. 2008;112(25):5593-7.

Parry CS, Brooks BR. A new model defines the minimal set of polymorphism in HLA-DQ and -DR that determines susceptibility and resistance to autoimmune diabetes. Biol Direct. 2008;3(1):42.

O'Brien EP, Stan G, Thirumalai D, Brooks BR. Factors Governing Helix Formation in Peptides Confined to Carbon Nanotubes. Nano Lett. 2008;8(11):3702-3708.

O'Brien EP, Ziv G, Haran G, Brooks BR, Thirumalai D. Effects of denaturants and osmolytes on proteins are accurately predicted by the molecular transfer model. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(36):13403-8.

Sherwood P, Brooks BR, Sansom MS. Multiscale methods for macromolecular simulations. Current Opinion in Structural Biology. 2008;18(5):630-40.

Larkin JD, Bhat KL, Markham GD, James TD, Brooks BR, Bock CW. A computational characterization of boron-oxygen multiple bonding in HN=CH-CH=CH-NH-BO. Journal of Physical Chemistry A. 2008;112(36):8446-54.

Damjanovic A, Wu X, Garcia-Moreno E B, Brooks BR. Backbone relaxation coupled to the ionization of internal groups in proteins: a self-guided langevin dynamics study. Biophys Journal. 2008;95(9):4091-101.

Damjanovic A, Miller BT, Wenaus TJ, Maksimovic P, Garcia-Moreno E B, Brooks BR. Open Science Grid Study of the Coupling between Conformation and Water Content in the Interior of a Protein. Journal of Chemical Information and Modeling. 2008;48(10):2021-2029.

Miller BT, Singh RP, Klauda JB, Hodoscek M, Brooks BR, Woodcock HL. CHARMMing: A New, Flexible Web Portal for CHARMM. Journal of Chemical Information and Modeling. 2008;48(9):1920-1929.

Woodcock HL, Brooks BR, Pastor RW. Pathways and populations: Stereoelectronic insights into the exocyclic torsion of 5-(hydroxymethyl)tetrahydropyran Journal of the American Chemical Society. 2008;130(20):6345-6347.

Klauda JB, Eldho NV, Gawrisch K, Brooks BR, Pastor RW. Collective and Noncollective Models of NMR Relaxation in Lipid Vesicles and Multilayers. Journal of Physical Chemistry B. 2008;112(19):5924-5929.

Miller BT, Zheng W, Venable RM, Pastor RW, Brooks BR. Langevin Network Model of Myosin. Journal of Physical Chemistry B. 2008;112(19):6274-6281.

Klauda JB, Roberts MF, Redfield RG, Brooks BR, Pastor RW. Rotation of Lipids in Membranes: Molecular Dynamics Simulation, 31P Spin-Lattice Relaxation, and Rigid-Body Dynamics. Biophysical Journal. 2008;94(8):3074-3083.

Klauda JB, Brooks BR. CHARMM Force Field Parameters for Nitroalkanes and Nitroarenes. Journal of Chemical Theory and Computation. 2008;4(1):107-115.

Larkin JD, Milkevich M, Bhat KL, Markham GD, Brooks BR, Bock CW. Dimers of Boroglycine and Methylamine Boronic Acid: A Computational Comparison of the Relative Importance of Dative versus Hydrogen Bonding Journal of Physical Chemistry A. 2008;112(1):125-133.

Lengyel JS, Stott KM, Wu XW, Brooks BR, Balbo A, Shuck P, Perham RN, Subramaniam S, Milne JLS. Extended polypeptide linkers establish the spatial architecture of a pyruvate dehydrogenase multienzyme complex. Structure. 2008;16(1):93-103.

Zheng W, Brooks BR, Hummer G. Protein conformational transitions explored by mixed elastic network models. Proteins: Structure, Function and Genetics. 2007;69(1):43-57.

Larkin JD, Bhat KL, Markham GD, Brooks BR, Lai JH, Bock CW. A computational investigation of the geometrical structure and protodeboronation of boroglycine, H2N-CH2-B(OH) 2. Journal of Physical Chemistry A. 2007;111(28):6489-500.

Woodcock HL, Hodošček M, Gilbert ATB, Gill PMW, Schaefer HF, Brooks BR. Interfacing Q-chem and CHARMM to perform QM/MM reaction path calculations. Journal of Computational Chemistry. 2007;28(9):1485-502.


Woodcock HL, Hodošček M, Brooks BR. Exploring SCC-DFTB paths for mapping QM/MM reaction mechanisms. Journal of Physical Chemistry A. 2007;111(26):5720-8.


Woodcock HL, Moran D, Pastor RW, MacKerell Jr. AD, Brooks BR. Ab initio modeling of glycosyl torsions and anomeric effects in a model carbohydrate: 2-ethoxy tetrahydropyran. Biophysical Journal. 2007;93(1):1-10.


Che Y, Brooks BR, Marshall GR. Protein recognition motifs: Design of peptidomimetics of helix surfaces. Biopolymers. 2007;86(4):288-97.


O'Brien EP, Dima RI, Brooks B, Thirumalai D. Interactions between hydrophobic and ionic solutes in aqueous guanidinium chloride and urea solutions: Lessons for protein denaturation mechanism. Journal of the American Chemical Society. 2007;129(23):7346-53.


Zheng W, Liao J, Brooks BR, Doniach S. Toward the mechanism of dynamical couplings and translocation in hepatitis C virus NS3 helicase using elastic network model. Proteins: Structure, Function and Genetics. 2007;67(4):886-96.


Klauda JB, Wu X, Pastor RW, Brooks BR. Long-range lennard-jones and electrostatic interactions in interfaces: Application of the isotropic periodic sum method. Journal of Physical Chemistry B. 2007;111(17):4393-400.


Klauda JB, Brooks BR. Sugar binding in lactose permease: Anomeric state of a disaccharide influences binding structure. Journal of Molecular Biology. 2007;367(5):1523-34.


Woodcock HL, Moran D, Brooks BR, Schleyer PVR, Schaefer HF. Carbene stabilization by aryl substituents. is bigger better? Journal of the American Chemical Society. 2007;129(12):3763-70.


Che Y, Brooks BR, Riley DP, Reaka AJH, Marshall GR. Engineering metal complexes of chiral pentaazacrowns as privileged reverse-turn scaffolds. Chemical Biology and Drug Design. 2007;69(2):99-110. Klauda JB,


Stan G, Lorimer GH, Thirumalai D, Brooks BR. Coupling between allosteric transitions in GroEL and assisted folding of a substrate protein. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(21):8803-8.


Klauda JB, Brooks BR, Pastor RW. Dynamical motions of lipids and a finite size effect in simulations of bilayers. Journal of Chemical Physics. 2006;125(14).


Larkin JD, Bhat KL, Markham GD, Brooks BR, Schaefer HF, Bock CW. Structure of the boronic acid dimer and the relative stabilities of its conformers. Journal of Physical Chemistry A. 2006;110(36):10633-42.


Zheng W, Brooks BR. Modeling protein conformational changes by iterative fitting of distance constraints using reoriented normal modes. Biophysical Journal. 2006;90(12):4327-36.


Zheng W, Brooks BR, Thirumalai D. Low-frequency normal modes that describe allosteric transitions in biological nanomachines are robust to sequence variations. Proceedings of the National Academy of Sciences of the United States of America. 2006;103(20):7664-9.


Tan M-L, Brooks BR, Ichiye T. Temperature dependence of diffusion properties of soft sticky dipole water. Chemical Physics Letters. 2006;421(1-3):166-70.


Klauda JB, Kučerka N, Brooks BR, Pastor RW, Nagle JF. Simulation-based methods for interpreting x-ray data from lipid bilayers. Biophysical Journal. 2006;90(8):2796-807.


Stan G, Brooks BR, Lorimer GH, Thirumalai D. Residues in substrate proteins that interact with GroEL in the capture process are buried in the native state. Proceedings of the National Academy of Sciences of the United States of America. 2006;103(12):4433-8.


Milne JLS, Wu X, Borgnia MJ, Lengyel JS, Brooks BR, Shi D, Perham RN, Subramaniam S. Molecular structure of a 9-MDa icosahedral pyruvate dehydrogenase subcomplex containing the E2 and E3 enzymes using cryoelectron microscopy. Journal of Biological Chemistry. 2006;281(7):4364-70.


Che Y, Brooks BR, Marshall GR. Development of small molecules designed to modulate protein-protein interactions. Journal of Computer-Aided Molecular Design. 2006;20(2):109-30.


Klauda JB, Brooks BR, Pastor RW. Dynamical motions of lipids and a finite size effect in simulations of bilayers. Journal of Chemical Physics. 2006;125(14).


Klauda JB, Pastor RW, Brooks BR. Adjacent gauche stabilization in linear alkanes: Implications for polymer models and conformational analysis. Journal of Physical Chemistry B. 2005;109(33):15684-6.


Wu X, Brooks BR. Isotropic periodic sum: A method for the calculation of long-range interactions. Journal of Chemical Physics. 2005;122(4):1-18.


Stan G, Brooks BR, Thirumalai D. Probing the "annealing" mechanism of GroEL minichaperone using molecular dynamics simulations. Journal of Molecular Biology. 2005;350(4):817-29.


Zheng W, Brooks BR. Probing the local dynamics of nucleotide-binding pocket coupled to the global dynamics: Myosin versus kinesin. Biophysical Journal. 2005;89(1):167-78.


Zheng W, Brooks BR. Normal-modes-based prediction of protein conformational changes guided by distance constraints. Biophysical Journal. 2005;88(5):3109-17.


Zheng W, Brooks BR, Doniach S, Thirumalai D. Network of dynamically important residues in the open/closed transition in polymerases is strongly conserved. Structure. 2005;13(4):565-77.


Klauda JB, Brooks BR, MacKerellJr. AD, Venable RM, Pastor RW. An ab initio study on the torsional surface of alkanes and its effect on molecular simulations of alkanes and a DPPC bilayer. Journal of Physical Chemistry B. 2005;109(11):5300-11.


Zheng W, Brooks B. Identification of dynamical correlations within the myosin motor domain by the normal mode analysis of an elastic network model. Journal of Molecular Biology. 2005;346(3):745-59.


Stan G, Brooks BR, Lorimer GH, Thirumalai D. Identifying natural substrates for chaperonins using a sequence-based approach. Protein Science. 2005;14(1):193-201.


2000-2004



Chu JW, Brooks BR, Trout BL. Oxidation of methionine residues in aqueous solutions: Free methionine and methionine in granulocyte colony-stimulating factor. Journal of the American Chemical Society. 2004;126(50):16601-7.


Chu JW, Yin J, Brooks BR, Wang DIC, Ricci MS, Brems DN, Trout BL. A comprehensive picture of non-site specific oxidation of methionine residues by peroxides in protein pharmaceuticals. Journal of Pharmaceutical Sciences. 2004;93(12):3096-102.


Wu X, Brooks BR. β-Hairpin folding mechanism of a nine-residue peptide revealed from molecular dynamics simulations in explicit water. Biophysical Journal. 2004;86(4):1946-58.


Lagüe P, Pastor RW, Brooks BR. Pressure-based long-range correction for lennard-jones interactions in molecular dynamics simulations: Application to alkanes and interfaces. Journal of Physical Chemistry B. 2004;108(1):363-8.


Janezic D, Brooks BR. Harmonic analysis of large systems. II. Comparison of different protein models. Journal of Computational Chemistry. 2004;16(12);1543-1553.


Wu X, Chen Y, Brooks BR, Su YA. The local maximum clustering method and its application in microarray gene expression data analysis. Eurasip Journal on Applied Signal Processing. 2004;2004(1):53-63.


Chu JW, Trout BL, Brooks BR. A super-linear minimization scheme for the nudged elastic band method. Journal of Chemical Physics. 2003;119(24):12708-17.


Wu X, Brooks BR. Self-guided langevin dynamics simulation method. Chemical Physics Letters. 2003;381(3-4):512-8.


Tan M-L, Fischer JT, Chandra A, Brooks BR, Ichiye T. A temperature of maximum density in soft sticky dipole water. Chemical Physics Letters. 2003;376(5-6):646-52.


Woodcock HL, Hodošček M, Sherwood P, Lee YS, Schaefer HF, Brooks BR. Exploring the quantum mechanical/molecular mechanical replica path method: A pathway optimization of the chorismate to prephenate claisen rearrangement catalyzed by chorismate mutase. Theoretical Chemistry Accounts. 2003;109(3):140-8.


Petrella RJ, Andricioaei I, Brooks BR, Karplus M. An improved method for nonbonded list generation: Rapid determination of near-neighbor pairs. Journal of Computational Chemistry. 2003;24(2):222-31.


Stan G, Thirumalai D, Lorimer GH, Brooks BR. Annealing function of GroEL: Structural and bioinformatic analysis. Biophysical Chemistry. 2003;100(1-3):453-67.


Wu X, Milne JLS, Borgnia MJ, Rostapshov AV, Subramaniam S, Brooks BR. A core-weighted fitting method for docking atomic structures into low-resolution maps: Application to cryo-electron microscopy. Journal of Structural Biology. 2003;141(1):63-76.


Das D, Eurenius KP, Billings EM, Sherwood P, Chatfield DC, Hodoŝĉek M, Brooks BR. Optimization of quantum mechanical molecular mechanical partitioning schemes: Gaussian delocalization of molecular mechanical charges and the double link atom method. Journal of Chemical Physics. 2002;117(23):10534-47.


Lee YS, Worthington SE, Krauss M, Brooks BR. Reaction mechanism of chorismate mutase studied by the combined potentials of quantum mechanics and molecular mechanics. Journal of Physical Chemistry B. 2002;106(46):12059-65.


Milne JLS, Shi D, Rosenthal PB, Sunshine JS, Domingo GJ, Wu X, Brooks BR, Perham RN, Henderson R, Subramaniam S. Molecular architecture and mechanism of an icosahedral pyruvate dehydrogenase complex: A multifunctional catalytic machine. EMBO Journal. 2002;21(21):5587-98.


Lipsitz RS, Sharma Y, Brooks BR, Tjandra N. Hydrogen bonding in high-resolution protein structures: A new method to assess NMR protein geometry. Journal of the American Chemical Society. 2002;124(35):10621-6.


Wu X, Wang S, Brooks BR. Direct observation of the folding and unfolding of a β-hairpin in explicit water through computer simulation. Journal of the American Chemical Society. 2002;124(19):5282-3.


Dolan EA, Venable RM, Pastor RW, Brooks BR. Simulations of membranes and other interfacial systems using P21 and pc periodic boundary conditions. Biophysical Journal. 2002;82(5):2317-25.


Sharma Y, Kwon OY, Brooks BR, Tjandra N. An ab initio study of amide proton shift tensor dependence on local protein structure. Journal of the American Chemical Society. 2002;124: 327-335.


Speelman B, Brooks BR, Post CB. Molecular dynamics simulations of human rhinovirus and an antiviral compound. Biophysical Journal. 2001;80(1):121-9.


Zhou J, Reich S, Brooks BR. Elastic molecular dynamics with self-consistent flexible constraints. Journal of Chemical Physics. 2000;112(18):7919-29.


Cheatham TE , Brooks RB., Kollman PA. Molecular modeling of nucleic acid structure. in Current Protocols in Nucleic Acid Chemistry. 2000;1:7.5.1-7.5.12. Wiley: New York.


Before 2000


Cheatham TE, Brooks BR. Recent advances in molecular dynamics simulation towards the realistic representation of biomolecules in solution. Theoretical Chemistry Accounts. 1998;99(5):279-88.


Enyedy IJ, Kovach IM, Brooks BR. Alternate pathways for acetic acid and acetate ion release from acetylcholinesterase: A molecular dynamics study. Journal of the American Chemical Society. 1998;120(32):8043-50.


Chatfield DC, Szabo A, Brooks BR. Molecular dynamics of staphylococcal nuclease: Comparison of simulation with 15N and 13C NMR relaxation data. Journal of the American Chemical Society. 1998;120(21):5301-11.


Bogusz S, Cheatham TE, Brooks BR. Removal of pressure and free energy artifacts in charged periodic systems via net charge corrections to the ewald potential. Journal of Chemical Physics. 1998;108(17):7070-84.


Lee YS, Hodoscek M, Brooks BR, Kador PF. Catalytic mechanism of aldose reductase studied by the combined potentials of quantum mechanics and molecular mechanics. Biophysical Chemistry. 1998;70(3):203-16.


Chatfield DC, Eurenius KP, Brooks BR. HIV-1 protease cleavage mechanism: A theoretical investigation based on classical MD simulation and reaction path calculations using a hybrid QM/MM potential. Journal of Molecular Structure: THEOCHEM. 1998;423(1-2):79-92.


Parry CS, Brooks BR, Matsunaga N, Amzel LM. Structures of some substituted nitrophenols determined by ab initio computation: On the origin of heterocliticity in anti-nitrophenol antibodies. Journal of Molecular Structure: THEOCHEM. 1997;398-399:555-63.


Eurenius KP, Chatfield DC, Brooks BR, Hodoscek M. Enzyme mechanisms with hybrid quantum and molecular mechanical potentials. I. theoretical considerations. International Journal of Quantum Chemistry. 1996;60(6):1189-200.


Feller SE, Pastor RW, Rojnuckarin A, Bogusz S, Brooks BR. Effect of electrostatic force truncation on interfacial and transport properties of water. Journal of Physical Chemistry. 1996;100(42):17011-20.


Bhattacharyya D, Brooks BR, Callahan L. Positioning of positively charged residues in the V3 loop correlates with HIV type 1 syncytium-inducing phenotype. AIDS Research and Human Retroviruses. 1996;12(2):83-90.


Steinbach PJ, Brooks BR. Hydrated myoglobin's anharmonic fluctuations are not primarily due to dihedral transitions. Proceedings of the National Academy of Sciences of the United States of America. 1996;93(1):55-9.


Hwang Y, Das R, Saltz J, Hodoscek M, Brooks B. Parallelizing molecular dynamics programs for distributed-memory machines. IEEE computational science & engineering. 1995;2(2):18-29.


Brooks BR, Janezic D, Karplus M. Harmonic-Analysis of Large System. 1. Methodology. Journal of Compuational Chemistry. 1995;16(12):1522-42.


Janezic D, Brooks BR.
Harmonic analysis of large systems. II. Comparison of different protein models. Journal of Computational Chemistry. 1995;16(12):1543-53.


Janezic D, Venable RM, Brooks BR.
Harmonic analysis of large systems. III. Comparison with molecular dynamics. Journal of Computational Chemistry. 1995;16(12):1554-66.


Chatfield DC, Brooks BR. HIV-1 protease cleavage mechanism elucidated with molecular dynamics simulation. Journal of the American Chemical Society. 1995;117(20):5561-72.


Brooks BR, Janezic D, Karplus, M. Harmonic-Analysis of Large Systems .1. Methodology. Journal of Computational Chemistry. 1995;16(12):1522-1542.


Durell SR, Brooks BR, Ben-Naim A. Solvent-induced forces between two hydrophilic groups. Journal of Physical Chemistry. 1994;98(8):2198-202.


Steingbach PJ, Brooks BR. New Spherical-Cutoff Methods for Long-Range Forces in Macromolecular Simulation. Journal of Compuational Chemistry. 1994;15(7):667-683.


Steinbach PJ, Brooks BR. Protein hydration elucidated by molecular dynamics simulation. Proceedings of the National Academy of Sciences of the United States of America. 1993;90(19):9135-9.


Venable RM, Brooks BR, Carson FW. Theoretical studies of relaxation of a monomeric subunit of HIV-1 protease in water using molecular dynamics. Proteins: Structure, Function and Genetics. 1993;15(4):374-84.


Osawa Y, Darbyshire JF, Steinbach PJ, Brooks BR. Metabolism-based transformation of myoglobin to an oxidase by BrCCl3 and molecular modeling of the oxidase form. Journal of Biological Chemistry. 1993;268(4):2953-9.


Chandrasekhar I, Clore GM, Szabo A, Gronenborn AM, Brooks BR. A 500 ps molecular dynamics simulation study of interleukin-1β in water. correlation with nuclear magnetic resonance spectroscopy and crystallography. Journal of Molecular Biology. 1992;226(1):239-50.


Loncharich RJ, Brooks BR, Pastor RW. Langevin dynamics of peptides: The frictional dependence of isomerization rates of N-acetylalanyl-N'-methylamide. Biopolymers. 1992;32(5):523-35.


Loncharich RJ, Brooks BR. Temperature dependence of dynamics of hydrated myoglobin. comparison of force field calculations with neutron scattering data. Journal of Molecular Biology. 1990;215(3):439-55.


Raghunathan G, Seetharamulu P, Brooks BR, Guy HR. Models of δ-hemolysin membrane channels and crystal structures. Proteins: Structure, Function and Genetics. 1990;8(3):213-25.


Weston A, Newman MJ, Mann DL, Brooks BR. Molecular mechanics and antibody binding in the structural analysis of polycyclic aromatic hydrocarbon-diol-epoxide - DNA adducts. Carcinogenesis. 1990;11(5):859-64.


Han K, Syi J, Brooks BR, Ferretti JA. Solution conformations of the B-loop fragments of human transforming growth factor α and epidermal growth factor by 1H nuclear magnetic resonance and restrained molecular dynamics. Proceedings of the National Academy of Sciences of the United States of America. 1990;87(7):2818-22.


Pastor RW, Brooks BR, Szabo A. An analysis of the accuracy of Langevin and molecular dynamics algorithms. Molecular Physics. 1989;65(6):1409-1419.


Loncharich RJ, Brooks BR. The effects of truncating long-range forces on protein dynamics. Proteins. 1989;6(1):32-45.


Brooks BR, Pastor RW, Carson FW. Theoretically determined three-dimensional structure for the repeating tetrapeptide unit of the circumsporozoite coat protein of the malaria parasite plasmodium falciparum. Proceedings of the National Academy of Sciences of the United States of America. 1987;84(13):4470-4.


Post CB, Brooks BR, Karplus M, Dobson CM, Artymiuk PJ, Cheetham JC, Phillips DC. Molecular dynamics simulations of native and substrate-bound lysozyme. A study of the average structures and atomic fluctuations. Journal of Molecular Biology. 1986;190(3):455-79.


Irikura KK, Tidor B, Brooks BR, Karplus M. Transition from B to Z DNA: Contribution of internal fluctuations to the configurational entropy difference. Science. 1985;229(4713):571-2.


Brooks B, Karplus M. Normal modes for specific motions of macromolecules: Application to the hinge-bending mode of lysozyme. Proceedings of the National Academy of Sciences of the United States of America. 1985;82(15):4995-9.


Tidor B, Irikura KK, Brooks BR, Karplus M. Dynamics of DNA oligomers. Journal of Biomolecular Structure and Dynamics. 1983;1(1):231-52.


Brooks BR, Bruccoleri RE, Olafson BD, States DJ, Swaminathan S, Karplus, M. CHARMM - A Program for Macromolecular Energy, Minimization, and Dynamics Calculations. Journal of Computational Chemistry. 1983; 4(2):187-217.


Brooks B, Karplus M. Harmonic dynamics of proteins: Normal modes and fluctuations in bovine pancreatic trypsin inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 1983;80(21 I):6571-5.


Trenary M, Casida ME, Brooks BR, Schaefer HF. Three isomers of the al-C2H2 system [33]. Journal of the American Chemical Society. 1979;101(6):1638-9.


Brooks BR, Schaefer HF. Sudden polarization: Pyramidalization of twisted ethylene. Journal of the American Chemical Society. 1979;101(2):307-11.


Brooks BR, Laidig WD, Saxe P, Goddard JD, Yamaguchi Y, Schaefer HF. Analytic gradients from correlated wave functions via the two-particle density matrix and the unitary group approach.
The Journal of Chemical Physics. 1980;72(8):4652-4653.

Brooks BR, Schaefer, HF. Graphical Unitary Group-Approach to the Electron Correlation Problem - Methods and Preliminary Applications. Journal of Chemical Physics. 1979;70(11):5092-5106.